[40F] Experiencing extreme fatigue, leg swelling, and unsteady walk

Patient Description

A 40-year-old female reports experiencing extreme fatigue that has worsened over time, significantly impacting her ability to perform daily activities. The fatigue is present throughout the day, notably at 9 am, 12 pm, 3 pm, and 6 pm. Despite using a CPAP machine following a positive sleep study, there has been no improvement. Additionally, she experiences persistent swelling in her legs, which worsens as the day progresses, and an unsteady walk since December 2022. She denies dizziness, shortness of breath, or changes in heart rate. Her medical history includes tingling in arms, numbness in hands and feet, GERD, difficulty swallowing, trouble concentrating, loss of short-term memory, loss of fine motor skills, ADHD, anxiety, rosacea, alopecia, neck and back pain, and fibromyalgia. She has a family history of autoimmune diseases and is allergic to sulfa medications. Current medications include torsemide, albuterol, oxybutynin, diclofenac, metroNIDAZOLE, clobetasol, hydroxychloroquine, Arazlo, zolpidem, pantoprazole, metformin, baclofen, sertraline, albuterol nebulizer solution, amphetamine-dextroamphetamine, pregabalin, minoxidil, bupropion, and ketoconazole shampoo.

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Arora's Assessment

What might be happening

Your symptoms of extreme fatigue, leg swelling, and unsteady walking could be related to several underlying conditions. Here are some possibilities:

  1. Chronic Fatigue Syndrome (CFS): Given the long duration and severity of your fatigue, CFS could be a consideration. This condition is characterized by extreme fatigue that doesn't improve with rest and can worsen with physical or mental activity. Diagnosis often involves ruling out other conditions.

  2. Fibromyalgia: You have a diagnosis of fibromyalgia, which can cause widespread pain, fatigue, and cognitive difficulties. This could be contributing to your symptoms, including trouble concentrating and memory issues.

  3. Medication Side Effects: Some of your medications, such as those for anxiety, depression, and pain management, can cause fatigue and dizziness as side effects. It's important to review these with your healthcare provider.

  4. Autoimmune Conditions: Given your family history and symptoms like tingling and numbness, an autoimmune condition could be contributing to your symptoms. Conditions like lupus or multiple sclerosis can cause fatigue, balance issues, and other neurological symptoms.

  5. Heart or Kidney Issues: The swelling in your legs, especially worsening throughout the day, could indicate fluid retention, which might be related to heart or kidney function. Torsemide is a diuretic used to manage fluid retention, but if symptoms persist, further evaluation may be needed.

What you can do

Extreme Fatigue:

  • Consult Your Doctor: It's important to discuss your persistent fatigue with your healthcare provider. They may recommend further testing or adjustments to your current treatment plan.
  • Lifestyle Adjustments: Ensure you are maintaining a balanced diet, staying hydrated, and getting regular, gentle exercise as tolerated. These can help manage fatigue levels.

Leg Swelling:

  • Elevate Your Legs: When resting, try to elevate your legs to help reduce swelling.
  • Compression Stockings: Consider wearing compression stockings to help manage swelling. These can be purchased online or at a pharmacy.

Unsteady Walking:

  • Physical Therapy: A physical therapist can help improve your balance and strength, which may help with your unsteady walking.
  • Home Safety: Ensure your home is safe to prevent falls, such as removing tripping hazards and using assistive devices if needed.

Medication Review:

  • Discuss with Your Doctor: Review your current medications with your healthcare provider to identify any that might be contributing to your symptoms. Adjustments or alternatives may be available.

Symptom Tracking:

  • Use MDandMe: Consider using MDandMe to journal your symptoms, track your progress, and share insights with your healthcare provider. This can help in managing your condition and adjusting your treatment plan as needed.

What you should look out for

Seek medical attention if you experience any of the following:

  • Sudden worsening of symptoms, such as increased fatigue or swelling
  • New symptoms, such as chest pain, shortness of breath, or severe dizziness
  • Any signs of infection, such as fever or redness and warmth in swollen areas

Remember, while this advice can help guide you, it's important to consult with your healthcare provider for a formal diagnosis and personalized treatment plan.

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3 mo ago

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People Also Ask


What could be causing my extreme fatigue despite using a CPAP machine?

Extreme fatigue despite using a CPAP machine could be due to conditions like Chronic Fatigue Syndrome or fibromyalgia, medication side effects, or an underlying autoimmune condition. It's important to consult with your healthcare provider for further evaluation.


Why am I experiencing swelling in my legs that worsens throughout the day?

Swelling in the legs that worsens throughout the day could be due to fluid retention, possibly related to heart or kidney issues. It's important to discuss this with your doctor, as they may need to adjust your treatment or conduct further tests.


Could my medications be contributing to my symptoms of fatigue and unsteady walking?

Yes, some medications, especially those for anxiety, depression, and pain management, can cause fatigue and dizziness as side effects. It's important to review your medications with your healthcare provider to identify any that might be contributing to your symptoms.


What are some potential causes of my unsteady walking and balance issues?

Unsteady walking and balance issues could be caused by fibromyalgia, an autoimmune condition, or side effects from medications. It's important to consult with your healthcare provider for a thorough evaluation and to consider physical therapy to help improve balance and strength.


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