[33F] With chronic fatigue, inflammation, and positive ANA

Patient Description

A 33-year-old female reports experiencing significant fatigue for over two years, exacerbated by standing and simple tasks, impacting her ability to work full-time and engage in hobbies or housework. She also experiences chest tightness, described as difficulty getting a full breath, with a severity of 8 out of 10, persisting for over a year. Daily inflammation is most prominent in the spine and legs, with nerve pain in the lower back and extremities. Sinus headaches have been present since her teenage years, described as throbbing with sharp pains behind the eyes and nose, ranging from 6 to 10 in intensity. Hair thinning has been noted all over the scalp for about a year, with a loss of more than a quarter but less than half of its normal volume. Recent urinalysis showed protein and casts, with high CRP and positive ANA. Past medical history includes EBV, pneumonia, repeat abnormal Pap smears, ADHD, preeclampsia, and a tonsillectomy and septum surgery. Current medications include Low-ogestrel, Dexmethylphenidate, Gabapentin, Venlafaxine, Metoprolol, and Vitamin D, with no known allergies or side effects. A second appointment with a rheumatologist is scheduled.

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Arora's Assessment

What might be happening

Your symptoms suggest a complex condition that may involve multiple underlying issues. Here are some possibilities:

  1. Autoimmune Disease:

    • A positive ANA and high CRP can indicate an autoimmune condition like lupus or rheumatoid arthritis. These conditions can cause fatigue, joint pain, inflammation, and rashes.
    • Testing may include specific antibody tests and imaging studies to assess joint and organ involvement.
  2. Kidney Involvement:

    • Protein and blood in your urine, along with urine casts, suggest possible kidney involvement, which can occur in autoimmune diseases.
    • A nephrologist might perform further tests, such as a kidney biopsy, to determine the cause.
  3. Fibromyalgia or Chronic Fatigue Syndrome:

    • Your widespread pain, fatigue, and headaches could be related to fibromyalgia or chronic fatigue syndrome.
    • Diagnosis is often clinical, based on symptoms and ruling out other conditions.
  4. Degenerative Disc Disease:

    • Your history of disc degeneration and nerve pain may contribute to your symptoms, including back pain and stiffness.
    • Treatment often involves pain management, physical therapy, and sometimes surgical interventions.

What you can do

Autoimmune Concerns:

  • Follow up with your rheumatologist to discuss your symptoms and any additional tests needed.
  • Keep a detailed journal of your symptoms using MDandMe to track patterns and triggers.

Kidney Health:

  • Stay hydrated and follow any dietary recommendations from your healthcare provider.
  • Monitor your blood pressure and report any significant changes to your doctor.

Pain and Fatigue Management:

  • Consider gentle exercises like yoga or swimming to maintain mobility without overexertion.
  • Practice stress-reduction techniques such as meditation or deep breathing exercises.

General Health:

  • Ensure a balanced diet rich in fruits, vegetables, and lean proteins to support overall health.
  • Prioritize rest and establish a regular sleep schedule to help manage fatigue.

What you should look out for

  • Seek immediate medical attention if you experience severe chest pain, difficulty breathing, or sudden changes in your symptoms.
  • Monitor for new symptoms such as swelling, unexplained weight changes, or increased pain.
  • Regularly review your medications with your healthcare provider to ensure they are still appropriate for your condition.

Remember, it's important to work closely with your healthcare team to get a comprehensive evaluation and personalized treatment plan.

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People Also Ask


What are the common symptoms of autoimmune diseases like lupus or rheumatoid arthritis?

Common symptoms of autoimmune diseases such as lupus or rheumatoid arthritis include fatigue, joint pain, inflammation, skin rashes, and sometimes organ involvement. Blood tests like ANA and CRP, along with specific antibody tests, can help in diagnosis.


How can kidney involvement be related to autoimmune diseases, and what tests might be needed?

Autoimmune diseases can cause inflammation in the kidneys, leading to protein and blood in the urine. Tests like urinalysis, blood tests, and possibly a kidney biopsy are used to assess kidney involvement.


What are the differences between fibromyalgia and chronic fatigue syndrome?

Fibromyalgia is characterized by widespread musculoskeletal pain, fatigue, and tenderness, while chronic fatigue syndrome primarily involves severe, persistent fatigue not improved by rest. Both conditions are diagnosed based on symptoms and exclusion of other diseases.


What lifestyle changes can help manage symptoms of degenerative disc disease?

Lifestyle changes for managing degenerative disc disease include regular low-impact exercises like swimming or yoga, maintaining a healthy weight, practicing good posture, and using ergonomic furniture. Pain management may also involve physical therapy and medications.


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Anonymous#63795

3 mo ago

Additionally reports-- difficulty finding words, forgetting, repeating questions, misspelling words, and halting speech. She experiences dizziness, balance issues, a falling sensation, and lightheadedness. The patient has high blood pressure and tingling sensations with purple/blue toes. She notes temperature intolerance, night sweats, muscle spasms, nausea, bloating, and acid reflux. Additionally, there is a red rash-like burning sensation on her cheeks, heart palpitations, and extremely dry skin, particularly on the face. Her scalp psoriasis has worsened. She reports dryness in ears, nose, mouth, eyes, and throat, with narrowed nasal passages. There is sensitivity to touch, swaying/rocking when still, frequent nighttime urination, loss of appetite, restless sleep, and vision issues like blurring and difficulty focusing. Symptoms of restless sleep have been present since her teenage years, worsening since 2022, with daily occurrences noted since early 2023. No family history of neurological disorders, autoimmune diseases, or metabolic conditions is known. No recent travel or exposure to new environments or substances.

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