[33F] Experiencing side effects from hormone therapy

Patient Description

A 33-year-old female began hormone therapy approximately three months ago to manage heavy menstrual bleeding. Since starting the medication, she has experienced persistent swelling in the left lower leg, which intensifies after taking the medication and does not fully resolve, although it decreases somewhat. The patient reports calf tightening associated with the swelling. Additionally, she experiences moderate to severe shortness of breath, particularly when standing up, which is relieved by sitting and resting. The patient also reports increased frequency of flatulence, occurring more than 40 times a day, especially when transitioning from lying down to standing up. There is no identified dietary trigger for the gas, and while stool frequency has increased, there are no changes in color. The patient has not yet discussed these symptoms with a healthcare provider.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, there are a few potential concerns:

  1. Deep Vein Thrombosis (DVT): The swelling and tightness in your left lower leg, especially if it's persistent, could indicate a blood clot. DVT is a serious condition that requires immediate medical attention to prevent complications like a pulmonary embolism.

  2. Side Effects of Hormone Therapy: Hormone therapy can sometimes cause fluid retention, leading to swelling. It can also affect your gastrointestinal system, potentially causing increased gas.

  3. Anemia: Your shortness of breath and fatigue, especially when standing or climbing stairs, could be related to anemia. Anemia can result from heavy menstrual bleeding and may require treatment to manage your symptoms effectively.

  4. Heart or Circulatory Issues: The combination of leg swelling, shortness of breath, and fatigue could also suggest a heart or circulatory problem, which would need prompt evaluation.

What you can do

  1. Seek Immediate Medical Attention: Given the potential for a serious condition like DVT, it's crucial to seek medical evaluation as soon as possible. If you experience worsening symptoms, such as chest pain or difficulty breathing, call 911 or have someone take you to the emergency room immediately.

  2. Consult Your Healthcare Provider: Discuss your symptoms with your healthcare provider, especially since they started after beginning hormone therapy. They may need to adjust your medication or investigate further.

  3. Monitor Your Symptoms: Keep track of any changes in your symptoms, such as increased swelling, pain, or changes in your breathing. This information will be helpful for your healthcare provider.

  4. Rest and Elevate Your Leg: While waiting for medical evaluation, try to rest and elevate your leg to reduce swelling. Avoid standing for long periods.

Remember, while I can provide information, it's essential to consult with a healthcare professional for a formal diagnosis and appropriate treatment.

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4 mo ago

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People Also Ask


What are the symptoms of Deep Vein Thrombosis (DVT)?

Symptoms of DVT include swelling in one leg, pain or tenderness in the leg, especially when standing or walking, warmth in the affected leg, and red or discolored skin. If you suspect DVT, seek medical attention immediately.


Can hormone therapy cause swelling and gastrointestinal issues?

Yes, hormone therapy can cause fluid retention, leading to swelling, and may also affect the gastrointestinal system, causing symptoms like increased gas and changes in bowel habits.


How can heavy menstrual bleeding lead to anemia?

Heavy menstrual bleeding can lead to anemia by causing a significant loss of red blood cells, which are necessary for carrying oxygen throughout the body. This can result in symptoms like fatigue, shortness of breath, and dizziness.


What are the signs of heart or circulatory problems related to leg swelling and shortness of breath?

Signs of heart or circulatory problems can include persistent leg swelling, shortness of breath, fatigue, chest pain, and palpitations. These symptoms warrant prompt medical evaluation to rule out serious conditions.


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