[31F] Experiencing fatigue, frequent infections, and weight loss

Patient Description

A 31-year-old female reports experiencing significant fatigue and a weakened immune system over the past year. She frequently contracts viral infections such as COVID-19, flu, colds, and strep throat. The patient has also experienced notable weight loss, although her weight has stabilized in recent months. Fatigue episodes last from a day to a week and occur every few days, impacting her daily activities. She reports constant, dull joint pain that occasionally worsens, dry skin on her shins, weak and brittle hair, and sporadic mouth sores, particularly during a COVID-19 infection. The patient experiences random fevers and has sporadic insomnia, though it does not seem linked to her fatigue. There is no known family history of autoimmune diseases, and she has no pre-existing conditions or medication allergies. She is not currently taking any medications.

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Arora's Assessment

What might be happening

Your symptoms could be related to several potential issues:

  1. Autoimmune Disease: Conditions like lupus or rheumatoid arthritis can cause fatigue, joint pain, and a weakened immune system. These diseases occur when the immune system attacks the body's own tissues.

  2. Chronic Fatigue Syndrome (CFS): This condition is characterized by extreme fatigue that doesn't improve with rest and may worsen with physical or mental activity.

  3. Nutritional Deficiencies: Deficiencies in vitamins or minerals, such as iron or vitamin D, can lead to fatigue and weakened immunity.

  4. Infections: Frequent infections and sporadic fevers might indicate an underlying issue with your immune system.

Typical treatments or tests might include blood tests to check for autoimmune markers, nutritional deficiencies, or infections. A healthcare provider might also recommend lifestyle changes or medications to manage symptoms.

What you can do

Fatigue and Immune System:

  • Consult a Healthcare Provider: It's important to see a doctor for a thorough evaluation. They may recommend blood tests or other diagnostics.
  • Healthy Lifestyle: Ensure a balanced diet rich in fruits, vegetables, and lean proteins. Regular exercise, adequate sleep, and stress management can also help.
  • Symptom Tracking: Use MDandMe to journal your symptoms, track progress, and share insights with your healthcare provider.

Joint Pain:

  • Gentle Exercise: Engage in low-impact activities like swimming or walking to maintain joint flexibility.
  • Pain Relief: Over-the-counter pain relievers like ibuprofen may help, but consult a doctor before use.

Dry Skin and Hair:

  • Moisturize: Use a good moisturizer for dry skin and consider gentle hair care products.
  • Hydration: Drink plenty of water to stay hydrated.

What you should look out for

Seek medical attention if you experience:

  • Persistent or worsening symptoms
  • New or severe joint swelling
  • High fevers or unexplained weight loss

Remember, it's important to consult with a healthcare professional for a formal diagnosis and treatment plan.

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3 mo ago

People Also Ask


What are common symptoms of autoimmune diseases like lupus or rheumatoid arthritis?

Common symptoms of autoimmune diseases such as lupus or rheumatoid arthritis include fatigue, joint pain, swelling, skin rashes, and fever. These conditions occur when the immune system mistakenly attacks healthy tissues in the body.


How can nutritional deficiencies affect the immune system and overall health?

Nutritional deficiencies, such as a lack of iron, vitamin D, or B vitamins, can lead to fatigue, weakened immunity, and other health issues. These nutrients are essential for energy production and maintaining a healthy immune system.


What lifestyle changes can help manage chronic fatigue syndrome?

To manage chronic fatigue syndrome, it's important to maintain a balanced diet, engage in regular low-impact exercise, ensure adequate sleep, and manage stress. Keeping a symptom diary can also help identify triggers and patterns.


When should someone seek medical attention for persistent fatigue and frequent infections?

Medical attention should be sought if fatigue and frequent infections persist or worsen, if there are new or severe symptoms like joint swelling, high fevers, or unexplained weight loss, as these could indicate an underlying health issue that needs to be addressed.


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