[31F] With persistent rash, oral blisters, and systemic symptoms

Patient Description

A 31-year-old female presents with a persistent body rash, blisters on the tongue (under, sides, back, and one at the tip), and sores in the nose for the past three months. The patient reports that the blisters have increased in size and cause pain, making it difficult to eat or drink. Additionally, she experiences itching in the mouth, private area, and body, which feels like a tingling or slight burning sensation. Her voice is almost gone, and she has a sore throat when swallowing. The patient also reports fatigue, joint pain, swollen lymph nodes, weight loss, night sweats, and dizziness since the rash appeared. She has no history of autoimmune diseases, has not been exposed to new environments, animals, or substances, and has not traveled recently. She is currently taking prenatal vitamins and has started taking Benadryl at night for the past two days. The patient is allergic to penicillin.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, several potential diagnoses come to mind:

  1. Allergic Reaction: Given that you were previously diagnosed with an allergic reaction, it's possible that you are still experiencing symptoms from an ongoing or chronic allergic response. This could explain the rash, itching, and blisters in your mouth and private area. However, the persistence and severity of your symptoms suggest that further evaluation is needed.

  2. Autoimmune Disease: Conditions like lupus or pemphigus vulgaris can cause widespread blistering, rashes, and systemic symptoms such as fatigue, joint pain, and swollen lymph nodes. These diseases can also cause mucosal involvement, leading to blisters in the mouth and nose.

  3. Infectious Causes: Viral infections like herpes simplex virus (HSV) or coxsackievirus (hand, foot, and mouth disease) can cause blisters in the mouth and throat, as well as systemic symptoms like fatigue and dizziness. However, these infections typically resolve within a few weeks, so a chronic infection is less likely but still possible.

  4. Nutritional Deficiencies: Deficiencies in certain vitamins and minerals, such as B vitamins, iron, or zinc, can cause symptoms like mouth sores, fatigue, and dizziness. However, this is less likely given that you are taking prenatal vitamins.

  5. Systemic Conditions: Conditions like Behçet's disease or Stevens-Johnson syndrome can cause widespread mucosal and skin involvement, along with systemic symptoms. These conditions are serious and require prompt medical attention.

What you can do

Blisters, Rash, and Itching:

  • See a doctor as soon as possible: Given the persistence and severity of your symptoms, it's important to seek medical attention. Your doctor may perform blood tests, skin biopsies, or other diagnostic tests to determine the underlying cause.
  • Avoid potential allergens: Since you were previously diagnosed with an allergic reaction, try to avoid any known or potential allergens, including certain foods, medications, or environmental triggers.
  • Use over-the-counter treatments: Continue taking Benadryl as directed to help manage itching. You can also use topical corticosteroids or antihistamine creams for the rash, but consult your doctor before starting any new treatments.

Throat Pain and Hoarseness:

  • Stay hydrated: Drink plenty of fluids to keep your throat moist and reduce irritation.
  • Use throat lozenges or sprays: These can help soothe your throat and reduce pain when swallowing.
  • Avoid irritants: Stay away from smoking, alcohol, and spicy foods, which can further irritate your throat.

Fatigue, Joint Pain, and Swollen Lymph Nodes:

  • Rest and manage stress: Ensure you get adequate rest and manage stress through relaxation techniques like deep breathing, meditation, or gentle exercise.
  • Monitor your symptoms: Keep track of your symptoms using the MDandMe journal to identify any patterns or triggers and share this information with your healthcare provider.

Weight Loss, Night Sweats, and Dizziness:

  • Consult your doctor: These symptoms can be concerning and may indicate an underlying systemic condition. Your doctor may need to perform additional tests to determine the cause.
  • Maintain a balanced diet: Ensure you are eating a nutritious diet to support your overall health and well-being.

What you should look out for

Given the severity and persistence of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Difficulty breathing or swallowing
  • Severe pain or swelling
  • High fever or chills
  • Rapid weight loss or extreme fatigue
  • New or worsening symptoms

Remember, while I can provide information and suggestions, it's important to consult with a healthcare professional for a formal diagnosis and appropriate treatment. If you have any more questions or need further assistance, feel free to continue the conversation.

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6 mo ago

People Also Ask


What could cause persistent blisters and sores in the mouth and nose?

Persistent blisters and sores in the mouth and nose can be caused by autoimmune diseases like pemphigus vulgaris or lupus, viral infections such as herpes simplex, or systemic conditions like Behçet's disease. It's important to consult a healthcare provider for a proper diagnosis.


Can an allergic reaction cause systemic symptoms like fatigue and joint pain?

Yes, an allergic reaction can cause systemic symptoms, but typically these are more acute. Chronic symptoms like fatigue and joint pain might suggest an underlying autoimmune condition or another systemic issue, so further evaluation by a healthcare professional is recommended.


What are some potential causes of weight loss, night sweats, and dizziness?

Weight loss, night sweats, and dizziness can be symptoms of various conditions, including infections, autoimmune diseases, or nutritional deficiencies. These symptoms warrant a thorough medical evaluation to determine the underlying cause.


How can I manage severe itching and rash at home?

To manage severe itching and rash at home, you can use over-the-counter antihistamines like Benadryl, apply topical corticosteroids or antihistamine creams, and avoid known allergens. However, it's crucial to consult with a doctor for persistent or severe symptoms.


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