[26M] With tonsillar swelling, night sweats, and armpit rash

Patient Description

A 26-year-old male presents with swollen tonsils for about a month, with increased prominence over the past week. The patient reports difficulty swallowing and a possible change in voice but denies fever or pus on the tonsils. Additionally, he experiences night sweats without associated fever, chills, weight loss, or fatigue. The patient also has a red, bumpy, and itchy rash in the armpit that has been present for almost two months, coming and going but not fully disappearing for a month. There is no history of exposure to new substances, medications, foods, or environmental factors. The patient occasionally consumes alcohol but does not use tobacco or recreational drugs. He is not currently taking any medications and has no significant family history of major illnesses or recent changes in sexual activity. No recent travel or exposure to infectious diseases reported.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

Swollen Tonsils and Night Sweats

  1. Infectious Mononucleosis (Mono):

    • Rationale: Mono is caused by the Epstein-Barr virus and can present with swollen tonsils, difficulty swallowing, and night sweats. It is common in young adults.
    • Typical Treatments/Testing: Blood tests to confirm the presence of the Epstein-Barr virus, rest, hydration, and over-the-counter pain relievers.
  2. Chronic Tonsillitis:

    • Rationale: Chronic inflammation of the tonsils can cause persistent swelling and discomfort. Night sweats can sometimes accompany chronic infections.
    • Typical Treatments/Testing: Throat swabs, antibiotics if bacterial, and possibly a referral to an ENT specialist for further evaluation.

Armpit Rash

  1. Contact Dermatitis:

    • Rationale: This could be due to an allergic reaction to deodorants, soaps, or other substances that come into contact with your skin.
    • Typical Treatments/Testing: Avoiding the irritant, using hypoallergenic products, and applying topical corticosteroids.
  2. Fungal Infection:

    • Rationale: Fungal infections can cause red, itchy, and bumpy rashes that persist and recur.
    • Typical Treatments/Testing: Antifungal creams or powders, keeping the area dry and clean.

Unifying Diagnosis

  1. Autoimmune Disorder:
    • Rationale: Conditions like lupus or Sjogren's syndrome can cause a variety of symptoms, including swollen tonsils, night sweats, and skin rashes.
    • Typical Treatments/Testing: Blood tests to check for autoimmune markers, referral to a rheumatologist.

What you can do

Swollen Tonsils and Night Sweats

  • See a doctor: It's important to get a proper diagnosis. Your doctor may perform blood tests or throat swabs to determine the cause.
  • At home:
    • Gargle with warm salt water to reduce throat discomfort.
    • Stay hydrated and get plenty of rest.
    • Use over-the-counter pain relievers like ibuprofen or acetaminophen to manage pain and fever.

Armpit Rash

  • See a doctor: A healthcare provider can help determine if the rash is due to an allergic reaction, infection, or another cause.
  • At home:
    • Avoid using any new or potentially irritating products on your skin.
    • Keep the area clean and dry.
    • Apply over-the-counter hydrocortisone cream to reduce itching and inflammation.

General Tips

  • Track your symptoms: Use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider.
  • Monitor your condition: Keep an eye on any changes in your symptoms and seek medical attention if they worsen or new symptoms develop.

What you should look out for

Given the severity and persistence of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Difficulty breathing or swallowing
  • High fever or chills
  • Severe pain or swelling
  • Rapidly spreading rash or signs of infection (e.g., pus, increased redness)

Remember, while I can provide some guidance, it's crucial to consult with a healthcare professional for a formal diagnosis and appropriate treatment.

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4 mo ago


People Also Ask


What could cause swollen tonsils without fever or pus?

Swollen tonsils without fever or pus can be caused by viral infections like infectious mononucleosis, chronic tonsillitis, or even an autoimmune disorder. It's important to consult a healthcare provider for accurate diagnosis and treatment.


Why might someone experience night sweats without a fever?

Night sweats without a fever can be associated with infections like mononucleosis, chronic infections, or even stress and anxiety. In some cases, they may also be a symptom of an underlying condition such as an autoimmune disorder.


What are common causes of a persistent, itchy rash in the armpit?

A persistent, itchy rash in the armpit can be caused by contact dermatitis, which is an allergic reaction to products like deodorants or soaps, or by a fungal infection, which thrives in warm, moist areas. Other causes could include eczema or psoriasis.


How can you differentiate between an allergic reaction and a fungal infection on the skin?

An allergic reaction, such as contact dermatitis, often occurs shortly after exposure to an irritant and may improve with avoidance of the irritant and use of topical corticosteroids. A fungal infection, on the other hand, may persist and recur, often requiring antifungal treatments and maintaining dryness in the affected area.


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