[25M] With recurrent genital blisters and history of chlamydia

Patient Description

A 25-year-old male presents with recurring small, fluid-filled bumps on his genitals that appear gradually and last for about 3-5 days every couple of months. These bumps sometimes occur after intercourse or when the patient feels he hasn't cleaned the area properly. The patient experiences pain, itching, or a burning sensation with these bumps. There are no other symptoms such as fever, body aches, swollen lymph nodes, or unusual discharge from the genitals. The patient tested positive for chlamydia in November 2022 and has had new sexual partners since then, but has not informed them about the previous STI diagnosis or had them tested. The patient has been tested for herpes (HSV-1 and HSV-2) with negative results. Additionally, the patient was told about traces of blood in the urine about a year ago but has no other pre-existing conditions or chronic illnesses. The patient has no allergies or adverse reactions to medications and is not currently taking any medications.

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Arora's Assessment

What might be happening

Based on the information you have provided, here are some possible explanations for your symptoms:

  • Genital Herpes: Despite your negative test results, genital herpes remains a possibility. Herpes simplex virus (HSV) can cause recurrent, small, fluid-filled blisters that are painful and itchy. These blisters can break open and form sores. Sometimes, initial tests can miss the infection, especially if it was done during a period without active symptoms.

    • Treatment: Antiviral medications like acyclovir, valacyclovir, or famciclovir can help manage outbreaks and reduce the frequency of recurrences. Your doctor may recommend a daily suppressive therapy if outbreaks are frequent.
  • Folliculitis: This is an inflammation of the hair follicles, often caused by bacterial or fungal infections. It can result in small, fluid-filled bumps that are itchy and painful.

    • Treatment: Good hygiene, topical antibiotics, or antifungal creams can help. Avoiding tight clothing and ensuring the area is clean and dry can also prevent recurrences.
  • Contact Dermatitis: This is a skin reaction to an irritant or allergen, which can cause fluid-filled blisters. Given that you sometimes notice the bumps after intercourse or when you feel you haven't cleaned the area properly, this could be a contributing factor.

    • Treatment: Identifying and avoiding the irritant or allergen is key. Topical corticosteroids can help reduce inflammation and itching.
  • Sexually Transmitted Infections (STIs): Other STIs, such as syphilis, can cause sores or blisters on the genitals. Given your history of chlamydia, it's important to consider other STIs as well.

    • Treatment: Specific antibiotics or antiviral medications are used depending on the STI. Regular screening and informing sexual partners are crucial steps.

What you can do

  1. Consult a Healthcare Provider: It's important to see a doctor for a formal diagnosis and appropriate treatment. They may recommend additional tests, including a repeat herpes test or other STI screenings.
  2. Maintain Good Hygiene: Keep the genital area clean and dry. Avoid using harsh soaps or products that could irritate the skin.
  3. Avoid Triggers: If you notice that certain activities or products trigger your symptoms, try to avoid them. This includes ensuring proper cleaning after intercourse.
  4. Use MDandMe: You can use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your healthcare provider. This can help in identifying patterns and triggers.
  5. Inform Sexual Partners: It's important to inform your sexual partners about your symptoms and encourage them to get tested. This helps in preventing the spread of potential infections.

What you should look out for

  • Worsening Symptoms: If the bumps become more frequent, severe, or do not heal within a week, seek medical attention.
  • Systemic Symptoms: If you develop a fever, body aches, or swollen lymph nodes, see a doctor promptly.
  • New Symptoms: If you notice any new symptoms such as unusual discharge, blood in your urine, or significant pain, consult a healthcare provider.

Remember, while I can provide information and suggestions, it's essential to seek care from real health professionals to receive a formal diagnosis and appropriate treatment.

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5 mo ago

People Also Ask


What are the common symptoms of genital herpes, and can it be missed in tests?

Common symptoms of genital herpes include small, fluid-filled blisters that are painful and itchy, which can break open and form sores. It can sometimes be missed in tests, especially if the test is done when there are no active symptoms. Repeat testing or testing during an outbreak may be more accurate.


How can folliculitis be distinguished from other skin conditions on the genitals?

Folliculitis can be distinguished by its appearance as small, fluid-filled bumps that are centered around hair follicles. It is often itchy and painful. A healthcare provider can help differentiate it from other conditions through examination and possibly a culture test.


What steps can be taken to prevent contact dermatitis in the genital area?

To prevent contact dermatitis in the genital area, identify and avoid potential irritants or allergens, such as certain soaps, detergents, or fabrics. Keeping the area clean and dry, and using hypoallergenic products can also help reduce the risk.


Why is it important to inform sexual partners about previous STI diagnoses?

Informing sexual partners about previous STI diagnoses is crucial to prevent the spread of infections. It allows partners to get tested and treated if necessary, and helps in making informed decisions about sexual health and safety.


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1 Comments


Billy#3955

5 mo ago

If you have tested negative for herpesvirus (HSV) and notice that the bumps are related to not cleaning your genital area, it sounds like the most likely explanation is folliculitis, which can present as blister-like (sometimes pus-filled) spots that can be painful or itchy. I'd suggest that you record when you get the blisters using the MDandMe journal and follow up with an "insights" chat in a month to see if folliculitis is the most likely explanation

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