[20F] With persistent swollen lymph node and frequent viral illnesses

Patient Description

A 20-year-old female has been experiencing a swollen lymph node on the left side of her neck for over a year. The lymph node is enlarged but not tender or painful, and its size fluctuates. She reports frequent and long-lasting viral illnesses, persistent fatigue, and infrequent soft diarrhea. She has not had any fevers but experiences hot flashes. Additionally, she has noticed unexplained weight loss and more frequent bowel movements. She also developed eczema that comes and goes and loses her voice every time she gets sick. The patient has a family history of autoimmune diseases or cancer and a past medical history of severe allergies and mild asthma, diagnosed at age 6. She is currently taking Allegra 180mg once daily, Bupropion 300mg once daily, Adderall XR 30mg once daily, and birth control. There are no known drug allergies.

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Arora's Assessment

What might be happening

Based on the information you've provided, several potential conditions could explain your symptoms:

  • Chronic Lymphadenopathy: Persistent swelling of a lymph node for over a year can be concerning. Chronic lymphadenopathy can be due to infections, autoimmune diseases, or even malignancies. Given your history of frequent and long-lasting viral illnesses, it's possible that a chronic or recurrent infection could be causing the lymph node to remain enlarged.

    • Typical Testing: Blood tests, imaging studies (like an ultrasound or CT scan), and possibly a biopsy of the lymph node to determine the cause.
    • Typical Treatment: Depends on the underlying cause. If it's an infection, antibiotics or antiviral medications may be needed. If it's related to an autoimmune condition, immunosuppressive drugs might be prescribed.
  • Immunodeficiency: Frequent and prolonged viral infections, along with persistent fatigue, could suggest an underlying issue with your immune system.

    • Typical Testing: Blood tests to evaluate immune function, including complete blood count (CBC) and immunoglobulin levels.
    • Typical Treatment: Depends on the specific type of immunodeficiency. Treatments may include immunoglobulin replacement therapy or other immune-modulating treatments.
  • Autoimmune Disorders: Conditions like lupus or rheumatoid arthritis can cause swollen lymph nodes, fatigue, and frequent infections. The sudden onset of eczema could also be related to an autoimmune process.

    • Typical Testing: Blood tests to check for specific autoantibodies, inflammatory markers, and other indicators of autoimmune activity.
    • Typical Treatment: Immunosuppressive medications, anti-inflammatory drugs, and lifestyle modifications.
  • Chronic Fatigue Syndrome (CFS): Characterized by persistent fatigue that doesn't improve with rest and may be accompanied by other symptoms like swollen lymph nodes and frequent infections.

    • Typical Testing: Diagnosis is often based on exclusion of other conditions. There are no specific tests for CFS.
    • Typical Treatment: Symptom management, including medications for pain and sleep disturbances, and lifestyle changes.

What you can do

  1. Consult a Doctor: It's crucial to see a healthcare professional for a thorough evaluation. They can order the necessary tests to determine the underlying cause of your symptoms.
  2. Maintain a Healthy Lifestyle: Eat a balanced diet, get regular exercise, and ensure adequate sleep. These can help support your immune system.
  3. Monitor Symptoms: Keep a diary of your symptoms, noting any changes or patterns. This information can be valuable for your doctor.

What you should look out for

Seek medical attention more urgently if you experience:

  • Rapid Weight Loss: Unexplained weight loss can be a sign of a serious underlying condition.
  • Severe Fatigue: If your fatigue worsens to the point that it significantly impacts your daily life.
  • New or Worsening Symptoms: Any new symptoms or a worsening of existing symptoms should prompt a visit to your doctor.
  • Persistent or High Fever: While you mentioned you don't get fevers, if this changes, it could indicate a more serious infection.

Remember, while this information can help guide you, it's essential to consult a healthcare professional for a formal diagnosis and appropriate treatment.

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7 mo ago

People Also Ask


What could cause a lymph node to remain swollen for over a year?

A lymph node that remains swollen for over a year could be due to chronic infections, autoimmune diseases, or malignancies. It's important to undergo medical evaluation, which may include blood tests, imaging, or a biopsy, to determine the cause.


How can frequent viral illnesses and persistent fatigue be related to an underlying health condition?

Frequent viral illnesses and persistent fatigue could suggest an issue with the immune system, such as immunodeficiency or an autoimmune disorder. These conditions can lead to a weakened ability to fight infections and cause chronic fatigue.


What are the potential implications of unexplained weight loss and more frequent bowel movements?

Unexplained weight loss and more frequent bowel movements can be concerning and may indicate an underlying condition such as a gastrointestinal disorder, metabolic issue, or even a malignancy. It's important to seek medical evaluation to determine the cause.


How might a family history of autoimmune diseases or cancer affect my current health symptoms?

A family history of autoimmune diseases or cancer can increase the risk of developing similar conditions. It is important to inform your healthcare provider about your family history, as it can guide the diagnostic process and management of your symptoms.


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